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Stay clear of use when using any oral drug that is certainly depending on threshold concentrations for efficacy. Interactions listed are consultant examples and don't contain all feasible medical examples.
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Reserve concomitant prescribing of these medicine in sufferers for whom other treatment alternatives are insufficient. Restrict dosages and durations to your minimal required. Watch intently for indications of respiratory melancholy and sedation.
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Starting over a 25mg dose might also be proposed When you have any hazard aspects which make you a lot more liable to side effects (like diabetes as an example).
codeine and olopatadine intranasal each maximize sedation. Prevent or Use Alternate Drug. Coadministration increases chance of CNS despair, which can result in additive impairment of psychomotor general performance and cause daytime impairment.
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abiraterone increases levels of codeine by affecting hepatic enzyme CYP2D6 metabolism. Use Caution/Monitor. Stay clear of coadministration of abiraterone with substrates of CYP2D6. If choice therapy cannot be utilized, work out caution and think about a dose reduction of the CYP2D6 substrate.
fentanyl transmucosal and codeine both improve sedation. Stay clear of or Use Alternate Drug. Restrict use click here to sufferers for whom alternate cure solutions are insufficient
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